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21 November 2059 was a fixed point in time: Bowie Base One, the first human colony on Mars, was destroyed and its crew was killed. The death of the captain, Adelaide Brooke, would inspire her granddaughter, Susie Fontana Brooke, to venture out into space, ensuring humanity's place among the stars. When the Tenth Doctor visited, the Flood infected the base. When Adelaide initiated Action 5, as per history, the base was, sixteen weeks into its mission, destroyed.
With the rebellious Doctor's intervention, defying the Laws of Time, Brooke, Yuri Kerenski and Mia Bennett were all saved and returned to Earth in his TARDIS. Disgusted by the "Time Lord Victorious", Adelaide shot herself, fixing the timelines, except dying on Earth instead. (TV: The Waters of Mars)
In 2119, the Drum brought aboard an alien spaceship during its mining operations. Jonathan Moran was killed by the "ghost" of Albar Prentis burning him alive with the spaceship's engines, so that Moran himself became a ghost to function as a transmitter for the spaceship's coordinates. (TV: Under the Lake)