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Nero threatened the First Doctor, stating he would build a moat around him and fill it with alligators. However, he changed his mind when the Doctor inadvertently inspired him to burn Rome. The Doctor told Nero's guards the punishment would be reserved for them if he and Vicki were not freed. (TV: "Inferno")
During the 22nd century Dalek invasion of Earth, many animals escaped from zoos during the plague. Most of them died, but reptiles such as the alligators thrived in the London sewers. An alligator almost attacked Susan, but was killed by David Campbell. (TV: The Dalek Invasion of Earth)
The First Doctor rescued the Chief Voord from alligators in a South American jungle. It was this act which convinced the Chief Voord to help the Doctor fight the Daleks. (PROSE: Doctor Who and the Daleks)