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The Royal Family had the blood mutation haemophilia which had also been called the "royal disease". The Tenth Doctor jovially suggested this was actually werewolf cells which Queen Victoria had passed to her children. He further suggested they might eventually mature in the 21st century. (TV: Tooth and Claw)
In 2006, following the crash of the Slitheen craft in Westminster, the Royal Family were evacuated. (TV: Aliens in London) On Christmas that year, all people with the blood type A+ were under the Sycorax's blood control. This included the Royal Family. (TV: The Christmas Invasion)
Over the years, people identified numerous suspects as Jack the Ripper, including members of the Royal Family. (PROSE: The Pit) Amy Pond had been sure it was someone from the Royal Family. The Eleventh Doctor blamed this on movies and said it made the truth look less far-fetched in comparison. (COMIC: Ripper's Curse)