Camille Coduri appeared semi-regularly in Doctor Who as Jackie Tyler beginning with the 2005 story, Rose. She made her last regular appearance on the series in the 2006 episode Doomsday. She later returned for the 2008 season finale, Journey's End and a cameo in David Tennant's final story, The End of Time. She also took part in The Weakest Link: Doctor Who Special and won £16,550.
In 2017, she returned to the role of Jackie in the Big Finish audio stories Retail Therapy (opposite Rose and the Ninth Doctor), Wednesdays For Beginners (opposite Jack Harkness), and Infamy of the Zaross (opposite Rose and the Tenth Doctor).
She featured in the film comedies Hawks (1988) (with Timothy Dalton), Nuns on the Run (1990) and King Ralph (1991). She has also appeared extensively on British television in guest roles in series such as Ashes to Ashes, Rumpole of the Bailey, Boon, A Touch of Frost and in the BBC's 1997 adaptation of Henry Fielding's novel The History of Tom Jones, a Foundling. In 2006 she appeared in BBC Three's six-part drama series iSinchronicity and she is a regular on BBC Three's Him & Her.