Cyclostimulators were a feature on spacecraft by at least the 372nd century.
The anti-matter creature caused the cyclostimulators of a Morestran probe ship sent to Zeta Minor in 37166 to fail as they had anti-matter minerals on board. They began working again, allowing the ship to leave the planet, when the Fourth Doctor fulfilled his promise to return the anti-matter taken by Professor Sorenson's expedition. (TV: Planet of Evil)
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