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The DNA bomb was an explosive designed by the hologram woman to latch on to John Hart's DNA. Knowing he would find some way around it, she split it into three cannisters and one eye, which she entrusted in a Blowfish, and told John it was an Arcadian diamond. She created a Rift storm, which took the Blowfish and cannisters to Cardiff. John killed her and used his vortex manipulator to ride the Riftstorm to Cardiff. The Blowfish was shot and killed by Jack Harkness and John collected the cannisters and the eye. The DNA bomb was activated, but John Deadlock sealed Gwen Cooper to him, forcing Torchwood Three to find a way to stop the bomb. Owen Harper injected John with blood samples of Torchwood workers and the bomb fell off. They threw it through the Rift storm John first came from. It blew up in the complexities of the Time Vortex, reversing time to the night John first came through. (TV: Kiss Kiss, Bang Bang)

A different kind of DNA bomb was used by Tim Shaw through his Gathering Coils as a simple yet merciless plan to take out witnesses. They were a micro-implant that would code to the victims DNA and would destroy the foundation of the genetic code upon detonation. This weapon was outlawed on every civilised galaxy according to the Thirteenth Doctor. She was able to remove the bomb from herself by reprogramming Ryan Sinclair's phone and shocking herself. She was then able to removed Ryan's, Graham's, Grace's and Yasmin's bombs after creating her sonic screwdriver. She then was able to implant them into Tim Shaw through his coils which he detonated believing them to still be attached to his victims. (TV: The Woman Who Fell to Earth) Though Tim Shaw survived, he was left badly wounded and trapped on Ranskoor Av Kolos due to his corrupted teleportation device. The effects of the bombs left Tim Shaw unable to leave the planet without dying. (TV: The Battle of Ranskoor Av Kolos)