Data was present on the ship's holodeck with William Riker and Beverly Crusher when the Doctor's TARDIS materialised in its "Dixon Hill" holonovel in 2368. The Eleventh Doctor noted that the sight of an android wearing a pinstripe suit in San Francisco in 1941 was unusual. Data along with Commander Riker and Doctor Crusher learned of the Doctor in the holodeck.
He was alerted of the attack of the planet Delta IV, where he told the captain and they began their journey there. They soon learned that it was the Borg and Cybermen attempting to assimilate the planet. Once the Borg and Cybermen learned of the Enterprise, Data navigated into a nearby nebula to confuse the opposing ship's sensors. Data under order from Captain Picard looked up any knowledge the Federation had of the Cybermen and he was the one to discover that the original Enterprise crew met a group of Cybermen.
Data confirmed that the Borg and Cybermen went to planet Cogen V.
The team made way to the main Cybership where Data, the Doctor and Picard were almost assimilated. The Cybermen noticed that Data on the other hand could not be upgraded. They were saved by the Enterprise with a gold beam and they soon made way to the Cyber-Controller. Data and the Conduit managed to pin the Cyber-Controller long enough for the Borg library to be restored. However, after the Cybership was set to self destruct, the Conduit attempted to assimilate the TARDIS. Data was possessed by its power and he managed to repel the Borg drone, which gave Worf and Rory the opportunity to throw him into the time vortex. (COMIC: Assimilation²)