It was infiltrated by the Krillitanes and was brought to the attention of Sarah Jane Smith and Mickey Smith separately. The Tenth Doctor and Rose Tyler were undercover in this school during the final stages of the Krillitane's plans, thanks to Mickey.
The school was heavily damaged in early 2007 when K9 destroyed a vat of Krillitane oil. All the human staff were killed by the Krillitanes, and all the Krillitanes were killed in the explosion. (TV: School Reunion)
In 2008 a student of Deffry Vale High School was taking part at Combat 3000, together with Luke Smith and Clyde Langer. Clyde couldn't remember his name but knew that he was a top footballer at Deffry Vale High School. (PROSE: Warriors of Kudlak)