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Being a complex and energetic closed system, N-Space, the main universe, had a finite lifespan and would have "died" some time prior to the 20th century had the Logopolitans not vented entropy from it into E-Space, another universe, via the CVEs which they created. (TV: Logopolis, PROSE: Timewyrm: Apocalypse)
In 1981, the Master interfered with the Logopolitan project and inadvertently closed the CVEs. A wave of entropy destroyed a large portion of the universe. On Logopolis, machines affected by entropy ceased to function and then crumbled. Parts of the Monitor, the Logopolitan leader, disappeared unevenly immediately prior to his actual disintegration. Whole stars and galaxies and many regions of the universe vanished, such as the Traken Union and Logopolis. The Logopolitans themselves were wiped out. (TV: Logopolis)