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The Daleks Edit
The Daleks had done extensive engineering to themselves and others. They had originally started as modified Kaleds. (TV: Genesis of the Daleks) Civil wars were known to be fought over genetic purity (TV: The Evil of the Daleks) and some Dalek technology, like the Progenitor, wouldn't recognise impure Daleks. (TV: Victory of the Daleks)
At one point, the Daleks searched for the Human Factor and the Dalek Factor, traits that distinguished humans and Daleks from other species. By implanting the Human Factor into Alpha, Beta, Omega and other Daleks, humanised Daleks were created. This led to the Great Civil War as the humanised Daleks questioned and rebelled against the Daleks' orders. The opposite procedure occurred when the Daleks implanted the Dalek Factor into Theodore Maxtible. (TV: The Evil of the Daleks) The Dalek Factor turned humans into Dalek servants and in some cases when they were mortally injured, they initiated a type of regeneration. (PROSE: I am a Dalek)
In 1930 New York City, the Cult of Skaro created two forms of Dalek-human hybrids. Dalek Sec became a human-Dalek after merging with Mr Diagoras, (TV: Daleks in Manhattan) and an army of hybrids were created by Dalek DNA implanted into near-dead humans with their minds wiped; these were also given Time Lord DNA after an attempt by the Tenth Doctor to destroy the transmitter on the top of the Empire State Building which powered their creation. He was struck by lightning, fusing his DNA into their genetic code. This made them question the Daleks' orders. (TV: Evolution of the Daleks) While in 1930 New York the Cult of Skaro implanted animal DNA into humans, turning them into pig slaves. (TV: Daleks in Manhattan)
Other species Edit
Ravus Oldeman created the Bloodhunter by combining DNA samples collected from the surface of Akoshemon with human DNA and force generating the resulting life form, in an attempt to create a creature capable of autonomous self-stasis. (PROSE: Fear of the Dark)