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George Layton played Technician Penn in the Doctor Who story The Space Pirates. He also voiced Stefan Lehne in the Big Finish Counter-Measures audio story Unto the Breach and Louis Markell/Human Guard in the Doctor Who audio story The Havoc of Empires.

He also played an actor playing the 'New Doctor' in the unaired French and Saunders sketch The Silurian Disruption.

Layton's other credits included Z-Cars, The Likely Lads, Dixon of Dock Green, The Liver Birds, Coronation Street, The Sweeney and The Bill. Layton became well known for his role of Dr Paul Collier on Doctor in the House and its sequels Doctor at Large, Doctor in Charge and Doctor at the Top. He is also known for playing Jimmy Stokes on United!, Brian Booth on My Brother's Keeper, Bombardier Solomons on It Ain't Half Hot Mum, Des on Minder and Norman Simmonds on EastEnders. Layton has also penned episodes of Doctor at Large, On the Buses, Doctor in Charge and Doctor at the Top.

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