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The human-Dalek hybrids were hybrids of Kaled mutants and humans, although typically the hybridised version of Dalek Sec was the one referred to as the human-Dalek. The other hybrids were the Dalek-humans.
Sec as human-Dalek was like a cross between a Dalek and a human form, with a Kaled mutant-shaped head (including six tentacles on the sides and with a partially-exposed brain), and brown, slimy skin. Other than that, he was identical to a human in all respects. He was also prone to feeling human emotions. When the mutant bonded with a human body, the metal casing acted like a cocoon, until the hybrid was fully developed.
The human-Dalek Edit
The human-Daleks originated out of the many experiments on Dalek flesh in the sewers of New York City in 1930. These experiments, research of the Cult of Skaro (who had temporally shifted from the Battle of Canary Wharf), resulted in the so-called "Final Experiment" after experiments to grow new Dalek embryos failed.
This "Final Experiment" involved Mr Diagoras, head of constructing the Empire State Building and the human selected as most Dalek-like, being merged with the body of Dalek Sec, leader of the Cult, inside the Black Dalek's casing. The experiment was to allow the Daleks to have a new life and to recreate the Dalek Empire. (TV: Daleks in Manhattan)
The Dalek-human-Time Lord army Edit
Later, the Daleks, under command of the human-Dalek, set to work combining the bodies of several hundred humans who had been placed into stasis with a mixture of Dalek and human DNA. However, the still-cyborg Daleks sabotaged the project, causing fully-Dalek DNA to enter the minds of the humans, instead of the hybrid forms.
However, the Tenth Doctor sabotaged this work by attempting to destroy the energy conductor at the top of the Empire State Building, and when this failed clung to the conductor as a solar flare lightning strike hit the conductor, causing the Doctor's Time Lord DNA coding to be mixed with the Daleks', creating Dalek-human-Time Lords who disobeyed the Daleks' orders (to the Daleks' surprise) and destroyed Daleks Thay and Jast. (TV: Evolution of the Daleks)
Destruction of the Dalek-humans Edit
Sec as a human-Dalek was the first to be destroyed, by Dalek Thay, standing in front of the Dalek's gunstick which was aimed at the Doctor.