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The International Space Station, or ISS, orbited Earth in the early 21st century. It was located 400 kilometres above the surface of the planet.

Canadian Chris Hadfield made a video of himself singing on the ISS, creating public interest in space exploration.

In 2015, the crew included Russian Dimitri Yemtov, South Korean Lee Jae-Yong, Cory, and Quinn led by Major Weir. That year, the ISS was destroyed by a Hyperion falling to Earth, killing the entire crew. (COMIC: The Hyperion Empire)

In the 2050s, the Tenth Doctor and Donna Noble visited the International Space Station, which was invaded by Mange Mites. (COMIC: Attack of the Mange Mites!)

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