Mandrake was a drug that was exploited by the Mandragora Helix in the 1990s in an attempt to conquer Earth. (COMIC: The Mark of Mandragora)
In 800, French king and Holy Roman Emperor Charlemagne lost a food taster to mandrake poisoning. (PROSE: The Lonely Computer)
In the 41st century, Erimem tricked Sekhmet into drinking her blood which was poisoned with distilled mandrake root that was contained in Erimem's signet ring. (AUDIO: The Bride of Peladon)