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Medusa has several meanings pertinent to the Doctor Who universe.
- Medusa, a Gorgon who came to Earth, and whose fictional construct was met by the Second Doctor and Zoe Heriot in TV: The Mind Robber.
- Medusa, an alien species who were trapped on Earth on COMIC: Gaze of the Medusa.
- Medusa Cascade, a region of space where the Earth and other planets were hidden by Davros in TV: The Stolen Earth
- Medusa (space station), a space station in orbit over the Phoenix colony that served as the main location for AUDIO: Three's a Crowd