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On Gallifrey, a mouse was enlarged by the Rani during an experiment. The giant-sized mouse ate the Lord President's pet cat and bit the President himself, which resulted in the Rani's expulsion from Gallifrey. (TV: The Mark of the Rani)
In Prague, the Master used the time winds to bring a dead mouse back to life and accelerate its evolution by millions of years into a humanoid form, which he planned to use as a new host body for himself, but the Seventh Doctor defeated the Master's plan. (PROSE: Omegamorphosis)