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Neve McIntosh played the recurring character Madame Vastra during the runs of the Eleventh and Twelfth Doctors and reprised the role for Big Finish in 2018. She also played several other Silurians - Alaya and Restac in the Series 5 two parter The Hungry Earth / Cold Blood, and Tryska and Kalana in Big Finish's UNIT: The New Series box set Assembled.

She is best known to fantasy fans for playing Lady Fuchsia in the 2000 miniseries Gormenghast. In the autumn of 2010, she co-starred in the BBC miniseries Single Father alongside David Tennant and Suranne Jones.

In 2012, she narrated the audio book version of the novel Dark Horizons.

In 2016, she voiced Lara Zannis in the Big Finish audio release The Shadow Vortex.

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