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In 1939, the War Lords used a nuclear reactor to power their base at Drachensberg. The Seventh Doctor set the reactor to overload, destroying the castle and the advanced technology contained in it. (PROSE: Timewyrm: Exodus)
In 1997, the Mars 97 was powered by two nuclear reactors constructed by Donneby's, making the vessel twice as fast as the old Mars Probes. Edward Greyhaven, having been betrayed by Lord Xznaal, programmed the reactors to overload and set the Mars Orbiter on a collision course with the Argyre clan's holdings, destroying them. (PROSE: The Dying Days)
Miss Myers connected a member of the metalkind to a nuclear reactor to give them enough power to summon their species to Earth so that they would be destroyed by Sky and the fleshkind would be victorious in their war. Rani Chandra described the complexity of shutting down a reactor to Clyde Langer as "James Bond meets Mario" but the two succeeded in shutting the reactor down before the metalkind arrived. (TV: Sky)
The planet Poytee was powered by global network of sub-surface atomic generators. When the populace became infected by the Tuloz Virus, the Science Corps wanted to vent the generators' coolant systems and create radioactive clouds to sterilise the planet. This plan was not used as the Fifth Doctor instead synthesised an antidote to the virus. (AUDIO: Urban Myths)