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Project Sub-Zero was a research project. It was being conducted at Snowcap University in 2048, and involved humans being engineered into hybrids via Dr Patricia Audley's experiments to survive the extreme cold of Antarctica. Known subjects included Quinn Norton, Polly Evans and Marianne. The Twelfth Doctor's suspicions were aroused when he was shown around the project, and noticed there were no living quarters. (COMIC: Blood and Ice)