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The Rassilon Imprimatur was linked to (or a part of) the symbiotic nuclei which allowed a Time Lord access to time travel and in particular temporal vessels such as TARDISes.

The Sixth Doctor once claimed that TARDISes (or other time machines) had to be primed with a Rassilon Imprimatur to enable them to travel safely in time. He said this knowing Stike was nearby, to fool him into letting the Doctor go for a trip in the Sontarans' Kartz-Reimer module. (TV: The Two Doctors)

The Imprimatur mapped Time Lords onto the time vortex as pure mathematics. (PROSE: Interference - Book One)

When a Gallifreyan was granted the rank of Junior Time Lord in the Time Lord Academy, they received their symbiotic nuclei. (PROSE: Interference - Book One)

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