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Retro-regeneration was the process of regenerations being forced in reverse, causing the Time Lord in question to revert to previous incarnations, (COMIC: The Fountains of Forever) known only to be attempted by Time Lords of the First Rank (PROSE: State of Change) though it was not known to be permanent in any cases. (COMIC: Timeslip, The Fountains of Forever, Outrun)
The Fourth Doctor and his TARDIS were once infected by a space amoeba, which caused him to and revert to his third, second, and first incarnations as he rapidly slid back through all of his past selves. (COMIC: Timeslip)
When The Then and the Now attempted to ingest the timeline of the Eleventh Doctor, it caused him to regress through his incarnations to the War Doctor, where the Doctor's resistance of that period of his life halted the ingestion. (COMIC: Outrun)