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Software were the instructions designed for computers to perform specific functions.
I2 was an Earth software company created by the Voracians. They planned to use the living software program Voractyll to take over the Earth, but were stopped by the Fourth Doctor. (PROSE: System Shock)
After escaping the laboratory where it had been built, the Hadax Ura went to the planet Unnamed BX-4. It uninstalled all of its diagnostic software, becoming insane as a result. (COMIC: Spirits of the Jungle)