On one occasion, the Eleventh Doctor recalled memories of his fourth incarnation meeting up with Spock and the command crew of the USS Enterprise to combat a Cyberman invasion of Aprilia III. (COMIC: Assimilation²)
A fictional character named Spock appeared in the science fiction television series Star Trek in the Doctor's universe. When the Third Doctor told Sgt. John Benton that he had visited a parallel universe, Benton asked, "You mean like that Star Trek episode where Spock had a beard?" (PROSE: The Face of the Enemy) This character was played by Leonard Nimoy, and at least once said, "The needs of the many outweigh the needs of the few." (PROSE: Lonely)
"Spock's Brain" was an episode of Star Trek which both Izzy Sinclair and Destrii had seen. Destrii even went so far as to call it her favourite. She cited "the bit where Sulu has to do the captain's log" as a particularly memorable moment and even quoted back a portion of the log, in unison with Izzy: "Captain Kirk's hunch that Spock's brain is on this planet appears to be correct!" (COMIC: Ophidius)
Spock was a character that Rose Tyler associated with a more "professional" approach to the use of technology. Whilst in London in 1941, she once bemoaned the Ninth Doctor's reliance on the sonic screwdriver and conversation as his primary investigative tools. She demanded that he "give [her] some Spock" in their search for a downed Chula ambulance. Later, in an effort to explain to Captain Jack Harkness who the Doctor was, she gave the Time Lord the alias "Mr Spock," because she suddenly realised that she didn't even know his proper name. (TV: The Empty Child)
Behind the scenes
The mentions of Mr Spock in The Face of the Enemy, Lonely, Ophidius, The Empty Child and The Nemonite Invasion treat him as a fictional character (as do, implicitly, other references to Star Trek and Star Trek: The Next Generation in Doctor Who stories). Assimilation² treats him as a "real" individual in an alternate dimension. This is similar to the treatment of Doctor Who in COMIC: TV Action! and COMIC: The Girl Who Loved Doctor Who.