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Circa 2009, Duroc went here to kill thirteen people to enter the physical world completely. (TV: Dead Man Walking) After that Angela Connolly, a doctor at the hospital, trapped a Hoix in the basement of the hospital. Owen Harper helped her tranquillise it. (TV: Exit Wounds)
Later that year, in September 2009, following a brief visit by Jack Harkness and Ianto Jones to pick up a "hitchhiker" from Mr Williams' dead body, Jack returned to investigate Mr Chow Lee Jee's cause of death and was fatally shot by secret British government agent Rupesh Patanjali. Patanjali himself was shortly afterwards shot to death by Johnson so he might not suspect the real reason that Patanjali sought help from Torchwood. (TV: Children of Earth: Day One)
In 2011, the Miracle Day phenomenon caused overcrowding as people with fatal conditions no longer died. A crowd of people massed by the hospital and some even worshipped the doctors. St Helen's had representatives visiting another, abandoned hospital to examine its possible use as storage for the overflowing ICU patients. (TV: Escape to LA)
Gwen Cooper was forced to leave hiding to visit her father in the hospital after suffering from a series of heart attacks. Gwen's husband, Rhys Williams, and her baby daughter, Anwen, accompanied her. (TV: The New World)