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Symbiotic nuclei were a part of Time Lord cells that allowed for safe time travel. (TV: The Two Doctors) The nuclei connected a Time Lord's mind to their TARDIS, meaning ships like the Master's TARDIS and the Doctor's TARDIS also possessed symbiotic nuclei. (AUDIO: The Evil One) TARDIS nuclei constantly updated the Matrix about their pilots. (AUDIO: The Brink of Death)

Symbiotic nuclei also enabled a Time Lord's ability to regenerate. (PROSE: Love and War) It was believed that a Time Lord could only regenerate twelve times because the nuclei could only divide so much. The Valeyard, however, claimed this was imposed by Rassilon to prevent a thirteenth regeneration and keep Time Lords from immortality. (AUDIO: Trial of the Valeyard)

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