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Time spillage was a temporal phenomenon which altered the flow of time. (TV: The Mark of the Rani) Alexhendri Lassiter defined time spillage as "quantum aberrations", a waste product caused by penetrating the Time Vortex. (PROSE: The Crystal Bucephalus) It was a form of time differential. Whether travelling backwards or forwards in time, an equal amount of time had to be accounted for, like conservation of energy. Osirans could absorb time spillage expended and use it to travel. (PROSE: The Sands of Time)
When the Rani visited Killingworth in the 19th century to gain the chemicals she needed on Miasimia Goria, the Sixth Doctor gained access to her TARDIS and tampered with the controls, making adjustments to the navigational system and velocity regulator. When the Rani dematerialised, her ship accelerated out of control and time spillage caused her tyrannosaurus rex embryo to rapidly mature. (TV: The Mark of the Rani)
Time spillage caused time shifts on a hotel suspended in the Vortex which had been exposed to time winds. When Jamie McCrimmon became ill from time spillage, the Second Doctor gave him a boiled sweet which made him feel better. (PROSE: Vortex of Fear)
The Crystal Bucephalus used adulterated dichronomide pentafiuorate to absorb time spillage, since it needed to be converted into something harmless like photons. Time spillage could not exist in the normal 11-dimensional universe as it was not compatible. (PROSE: The Crystal Bucephalus)
Ferran, in an attempt to kill the Eighth Doctor and Miranda Dawkins, decoupled the time engines of the Supremacy, throwing them out of phase and releasing time spillage which caused the engineers to rapidly age. (PROSE: Father Time)