Tottenham Court Road was the London street at whose McDonald's Ace worked as a waitress for a while. (PROSE: Illegal Alien, Head Games) It consisted mostly of electronic shops. (PROSE: The Crystal Bucephalus, Doctor Who and the Dinosaur Invasion) The version that Samantha Jones knew had places like a Burger King and, a Virgin Megastore so the place felt alien to her when he arrived there in 1963. (PROSE: The Taint) Mel Tyrone was almost always in that Burger King, (PROSE: The King of Terror) while Ace was browsing the Virgin Megastore during much of her free time. (PROSE: Illegal Alien) In the time period Ace was used to, and indeed many time periods, the road was constantly busy, with really heavy traffic at almost all times. (PROSE: Head Games)
Likewise, when Fitz Kreiner went to a London in his relative future, he was baffled by the electronic devices and televisions displayed in shop windows on Tottenham Court Road. (PROSE: Escape Velocity)
It was the location of the Warren Street tube station, (PROSE: The Indestructible Man) as well as the self-titled Tottenham Court Road station. (PROSE: Doctor Who and the Web of Fear, Heart of the TARDIS, Millennial Rites, Dead Romance) The street was also notable as the home of a little tea shop where Ian Chesterton and Barbara Wright first met. (PROSE: Byzantium!) The road also housed a police station. (PROSE: Endgame)
Hanway Street joined Tottenham and Oxford Street, (PROSE: The Quantum Archangel, Millennial Rites) although the connection between the two streets was later blocked by 1985. (PROSE: The Crystal Bucephalus) Tottemham was near Charing Cross Road. (PROSE: The Hollow Men)
Real world location
Though it's possible that a real world location doesn't exist in the same geographic space in the Doctor Who universe, such cases are few and far between. Thus, the map at right is probably a good indicator of the DWU location of Tottenham Court Road.