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Tycho Brahe was a Danish astronomer of the 16th century. The Tycho Project was named after him. (PROSE: The Last Sontaran) He studied at Charles University in Prague. (PROSE: The Long Step Backward) According to the Seventh Doctor, Brahe possessed a "scientific genius". (PROSE: Fable Fusion)

Tycho Brahe lost his nose in a duel, which was replaced by a facsimile. After Brahe's death, his body was buried in a cemetery in Prague. In the 24th century, his body was unearthed by the Third Doctor and Sergeant Kandula during the search for the Tipping Device. The Doctor said he was "an old friend". (PROSE: Midnight in the Café of the Black Madonna)